Shelby1975 wrote:
I use time machine, and have been very pleased with it. I would also like to use Backblaze for off site backup. Will these two work together and not cause any problems?

In general, they should stay out of each other's way.
Be sure BackBlaze is not trying to back up your Time Machine backups (I understand that's automatic, but it won't hurt to check).
I don't know exactly how it works, but some such apps keep some fairly large files on your system, apparently some sort of indexing or status data, that changes rapidly. By default, Time Machine will back that up, which may result in large TM backups (and backing-it up likely won't accomplish anything anyway). So check their documentation, and/or see #A2 in [Time Machine - Troubleshooting|http://web.me.com/pondini/Time_Machine/Troubleshooting.html] (or use the link in *User Tips* at the top of this forum), for a couple of apps that will show exactly what's backed-up. If you find something like that, exclude those files/folders from Time Machine, per #10 in [Time Machine - Frequently Asked Questions|http://web.me.com/pondini/Time_Machine/FAQ.html] (or use the link in *User Tips* at the top of this forum).